Moringa Oleifera plant may help improve cognition in people with alzheimer’s disease (AD)
Research on the cognitive related healing capabilities of Moring Oleifera (horseradish seeds) has confirmed ancient folklore of this miracle plant, which has been used for thousands of years, to treat cognitive dysfunction. This scientifically proven ability gives new hope for people suffering from Alzheimer’s Disease.
Previous research has shown that moringa oleifera is able to alter brain monoamines, which have a role in memory processing. Interestingly, people diagnosed with Alzheimer’s disease have their monoaminergic systems disturbed. An AD rat model study, investigated whether Moringa oleifera supplementation could alter brain monoamines (norepinephrine, dopamine and serotonin) in different areas of the brain affected by AD. They found that after moringa oleifera supplementation, the monoamines levels of the brain regions affected by AD were restored to near control levels.
The hippocampus plays an important role on spatial memory, and people diagnosed with Alzheminer disease have an altered neurogenesis, a process that happens in the hippocampus, by which neurons are generated from neural stem cells and progenitor cells. This dysfunction in the hippocampus is associated with Cognitive Impairment. However, supplementation with Moringa Oleifera leaves, in a rat model research, has discovered that after being administered 100mg/kg, the animals were able to retain and acquire knowledge, which is a proof of the possible neuroprotective effects of Moringa Oleifera.
Here is how Moringa oleifera acts on the brain of people with alzheimer’s disease
It is important to note that the occurrence of Alzheimer's disease (AD) is associated with the decrease in acetylcholine (ACh) neurotransmitters, which are affected by the enzymes cholinesterases [AChE and BChE] that have been reported to be responsible for the decline or insufficient ACh level in the synaptic gap of AD patients’ brain.
It is also well established that Increased activity of monoamine oxidase enzimes, have been linked with deactivation/reduction of neuroactive amine (dopamine, norepinephrine and serotonin) and increase in the production of reactive oxygen species, which leads to neurodegerative disturbances.
However, Moringa Oleifera seeds extract has been shown to have inhibitory abilities towards the enzymes cholinesterases [AChE and BChE] and monoamine oxidase enzymes. This ability to impact such biochemical reactions in the brain, give Alzheimer patients new hope in treating this disease that in the United States alone, affects over 5 million people.
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